abstract：BACKGROUND:Iodide organification defects are frequently but not always associated with mutations in the thyroid peroxidase (TPO) gene and characterized by a positive perchlorate discharge test. These mutations phenotypically produce a congenital goitrous hypothyroidism, with an autosomal recessive mode of inheritance. ...

journal_title：Clinical endocrinology

authors： Rivolta CM,Louis-Tisserand M,Varela V,Gruñeiro-Papendieck L,Chiesa A,González-Sarmiento R,Targovnik HM

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:Recent studies have shown that a relatively high number of diabetic patients may have unsuspected Cushing's syndrome (CS). The aim of the present study was to screen for CS in adult patients with newly diagnosed diabetes mellitus who were not selected for clinical characteristics, such as poor control and obe...

journal_title：Clinical endocrinology

authors： Reimondo G,Pia A,Allasino B,Tassone F,Bovio S,Borretta G,Angeli A,Terzolo M

更新日期：2007-08-01 00:00:00

abstract：UNLABELLED:A diagnosis of bilateral pheochromocytoma warrants exclusion of hereditary pheochromocytoma. OBJECTIVE:To describe the first case of a bilateral pheochromocytoma associated with V804M mutation in the RET proto-oncogene. PATIENTS:The index case was a 54-year-old man with bilateral adrenal masses discovered ...

journal_title：Clinical endocrinology

authors： Recasens M,Oriola J,Fernández-Real JM,Roig J,Rodríguez-Hermosa JI,Font JA,Galofre P,López-Bermejo A,Ricart W

更新日期：2007-07-01 00:00:00

abstract：:Objective African-Americans have been shown to have low prevalence of hypothyroidism. Brazil has a high ethnic admixture allowing further exploration into whether environmental factors can explain the ethnic differences. Design A survey, representative of the population of Rio de Janeiro, a large metropolitan city in ...

journal_title：Clinical endocrinology

authors： Sichieri R,Baima J,Marante T,de Vasconcellos MT,Moura AS,Vaisman M

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:The best method for determining hydrocortisone replacement therapy is not well defined. This study aimed to assess interindividual variability in cortisol pharmacokinetics and to investigate whether measurement of salivary cortisol provides a useful alternative to plasma concentration measurements. DESIGN:In...

journal_title：Clinical endocrinology

authors： Thomson AH,Devers MC,Wallace AM,Grant D,Campbell K,Freel M,Connell JM

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to observe the changes in bone and mineral metabolism and to confirm the regulation of fibroblast growth factor-23 (FGF-23) in untreated Graves' disease. PATIENTS AND MEASUREMENTS:The study comprised 39 patients, with or without Graves' disease. The Graves' disease group was made up...

journal_title：Clinical endocrinology

authors： Park SE,Cho MA,Kim SH,Rhee Y,Kang ES,Ahn CW,Cha BS,Lee EJ,Kim KR,Lee HC,Lim SK

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVES:The Asp727Glu polymorphism in the TSH receptor (TSHR) gene is associated with serum TSH levels. However, the proportion of genetic variation accounted for by this polymorphism is unknown. In this study, we (1) examined the association of the Asp727Glu polymorphism with thyroid size, serum levels of TSH, thyr...

journal_title：Clinical endocrinology

authors： Hansen PS,van der Deure WM,Peeters RP,Iachine I,Fenger M,Sørensen TI,Kyvik KO,Visser TJ,Hegedüs L

更新日期：2007-06-01 00:00:00

abstract：:Radioiodine has been in use for over 60 years as a treatment for hyperthyroidism. Major changes in clinical practice have occurred with the realization that accurate dosimetry is incapable of avoiding the risks of hypothyroidism, while more accurate assessment of the risks of other adverse effects of radioiodine such ...

journal_title：Clinical endocrinology

authors： Weetman AP

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:The metabolic syndrome has been associated with increased mortality in some Caucasian populations, but data in Asian populations are not available. We present data describing the association of the metabolic syndrome with mortality. METHODS:The impact of the US National Cholesterol Education Program Adult Tr...

journal_title：Clinical endocrinology

authors： Thomas GN,Schooling CM,McGhee SM,Ho SY,Cheung BM,Wat NM,Janus ED,Lam KS,Lam TH,Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee.

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:There is increasing evidence that antenatal stress has long-lasting effects on child development, but there is less accord on the mechanisms and the gestational window of susceptibility. One possible mechanism is by foetal exposure to maternal cortisol. To explore this, we investigated the relationship betwee...

journal_title：Clinical endocrinology

authors： Sarkar P,Bergman K,Fisk NM,O'Connor TG,Glover V

更新日期：2007-05-01 00:00:00

abstract：:The growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis plays an important role in modulating the peripheral metabolism of glucocorticoids mainly through its effect on the isoenzyme 11 beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) which, in vivo, functions as a reductase catalysing the conversion of cortis...

journal_title：Clinical endocrinology

authors： Agha A,Monson JP

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:Relationship between adult growth hormone deficiency (AGHD) and increased cardiovascular disease risk is very well known in hypopituitary patients treated with conventional hormone replacement therapy other than growth hormone (GH) administration. Endothelial dysfunction, an early and reversible event in path...

journal_title：Clinical endocrinology

authors： Oflaz H,Sen F,Elitok A,Cimen AO,Onur I,Kasikcioglu E,Korkmaz S,Demirturk M,Kutluturk F,Pamukcu B,Ozbey N

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Obestatin is a novel hormone that is encoded by the Ghrelin gene and produced in the gut. Ghrelin is profoundly orexogenic and adipogenic, increasing food intake and body weight. This new ghrelin-associated peptide behaves as a physiological opponent of ghrelin in rodent animals, but its pathophysiological r...

journal_title：Clinical endocrinology

authors： Qi X,Li L,Yang G,Liu J,Li K,Tang Y,Liou H,Boden G

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Hospital-acquired hyponatraemia is a common and potentially serious condition. Risk factors for hospital-acquired hyponatraemia have not been studied in a controlled fashion. Methods From 1501 patients in whom serum sodium (S(Na)) was determined, 50 cases with hospital-acquired hyponatraemia (in-hospital dec...

journal_title：Clinical endocrinology

authors： Beukhof CM,Hoorn EJ,Lindemans J,Zietse R

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:There is compelling evidence that insulin resistance may play a pivotal role in the development of pregnancy complications including pre-eclampsia and intrauterine growth restriction (IUGR). As dysregulation of visfatin and adiponectin is found in insulin resistance, both adipokines might contribute to pregna...

journal_title：Clinical endocrinology

authors： Fasshauer M,Blüher M,Stumvoll M,Tönessen P,Faber R,Stepan H

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity. We evaluated, in a 5-year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese. DESIGN AND PATIENTS:We conducted a ...

journal_title：Clinical endocrinology

authors： Xu JY,Sham PC,Xu A,Tso AW,Wat NM,Cheng KY,Fong CH,Janus ED,Lam KS

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:We examined the individual pharmacological effects of the addition of rosiglitazone and metformin to glimepiride on inflammatory markers and adipokines in patients with type 2 diabetes mellitus. We analysed the relationships between these variables, the measurements of insulin sensitivity and beta-cell functi...

journal_title：Clinical endocrinology

authors： Kim HJ,Kang ES,Kim DJ,Kim SH,Ahn CW,Cha BS,Nam M,Chung CH,Lee KW,Nam CM,Lee HC

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:Standard drug information resources recommend that l-thyroxine be taken half an hour before breakfast on an empty stomach, to prevent interference of its intestinal uptake by food or medication. We observed cases in which TSH levels improved markedly after changing the administration time of l-thyroxine to th...

journal_title：Clinical endocrinology

authors： Bolk N,Visser TJ,Kalsbeek A,van Domburg RT,Berghout A

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Expression of ghrelin has been reported in pancreatic endocrine tumours, but data on ghrelin receptor protein expression are lacking. The aim of this study was to examine the ghrelin receptor, as well as ghrelin, in a selected series of these tumours, including multiple endocrine neoplasia 1 (MEN1) associated...

journal_title：Clinical endocrinology

authors： Ekeblad S,Lejonklou MH,Grimfjärd P,Johansson T,Eriksson B,Grimelius L,Stridsberg M,Stålberg P,Skogseid B

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:The study was designed to examine the effect of percutaneous coronary intervention (PCI) on adiponectin and leptin levels. We have previously demonstrated that PCI triggers a systemic inflammatory response. We hypothesized that inflammation participates in the pathogenesis of diabetes mellitus and the metabol...

journal_title：Clinical endocrinology

authors： Azar RR,Sarkis A,Salameh E,Gannagé-Yared MH,Amm-Azar M,Badaoui G,Germanos M,Kassab R

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:To study circulating adiponectin concentrations in relation to diabetes duration and endogenous insulin secretion in patients with type 1 diabetes. PATIENTS:Patients with haemoglobin A1c (HbA1c) < 6% (reference range 3.6-5.4%) were selected for the study. Twenty-two men and 24 women [age 41.3 +/- 13.8 years ...

journal_title：Clinical endocrinology

authors： Lindström T,Frystyk J,Hedman CA,Flyvbjerg A,Arnqvist HJ

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVES:Associations between calcium-sensing receptor (CaSR) polymorphisms and serum calcium, PTH and bone mineral density (BMD) have been reported by six studies. However, three other studies have failed to detect such associations. We therefore further investigated three CaSR coding region polymorphisms (Ala986Ser...

journal_title：Clinical endocrinology

authors： Harding B,Curley AJ,Hannan FM,Christie PT,Bowl MR,Turner JJ,Barber M,Gillham-Nasenya I,Hampson G,Spector TD,Thakker RV

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Between 10 and 30% of the fine needle aspiration biopsies (FNABs) of thyroid nodules are diagnosed as 'indeterminate'. A molecular diagnostic method is needed to reduce unnecessary surgery in this group. In Korea, most thyroid cancer is the classic papillary type and the BRAF(V600E) mutation is highly preval...

journal_title：Clinical endocrinology

authors： Chung KW,Yang SK,Lee GK,Kim EY,Kwon S,Lee SH,Park DJ,Lee HS,Cho BY,Lee ES,Kim SW

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:Mutations of the PROP1 gene lead to combined pituitary hormone deficiency (CPHD), which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less frequently, ACTH. This study was undertaken to investigate the molecular defect in a cohort of patients with CPHD. DESIGN, PATIENTS AND MEASUREMENTS:A mul...

journal_title：Clinical endocrinology

authors： Lemos MC,Gomes L,Bastos M,Leite V,Limbert E,Carvalho D,Bacelar C,Monteiro M,Fonseca F,Agapito A,Castro JJ,Regateiro FJ,Carvalheiro M

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Iodide (I(-)) is crucial for foetal thyroid function. Foetal iodide results from maternal circulating iodide and from deiodination of iodothyronines within the placenta. The Na(+)/I(-) symporter (NIS) localized in placental cells appears to be involved in iodide exchange. Low NIS expression has been reported...

journal_title：Clinical endocrinology

authors： Di Cosmo C,Fanelli G,Tonacchera M,Ferrarini E,Dimida A,Agretti P,De Marco G,Vitti P,Pinchera A,Bevilacqua G,Naccarato AG,Viacava P

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE AND DESIGN:Depot somatostatin analogues are well accepted as either adjuvant or primary therapy for acromegaly, and their long dosage intervals facilitate adherence to treatment. Our objective was to evaluate whether lanreotide Autogel 120 mg, every 4-8 weeks, was as effective in controlling acromegaly as lan...

journal_title：Clinical endocrinology

authors： Lucas T,Astorga R,Spanish-Portuguese Multicentre Autogel Study Group on Acromegaly.

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:The protein-tyrosine-phosphate nonreceptor 22 gene (PTPN22) has recently been identified as a susceptibility locus for a number of autoimmune diseases including Graves' disease (GD). PTPN21 is another member of the PTPN family and its gene PTPN21 maps to the first reported region of genetic linkage to GD, GD-...

journal_title：Clinical endocrinology

authors： Zeitlin AA,Heward JM,Brand OJ,Newby PR,Franklyn JA,Gough SC,Simmonds MJ

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:Mutations in the melanocortin-4 receptor gene (MC4R) are the most common monogenic form of human obesity. However, the contribution of MC4R mutations to obesity in Chinese has not been investigated. We studied the frequency of MC4R mutations in an obese southern Chinese population and the functional consequen...

journal_title：Clinical endocrinology

authors： Rong R,Tao YX,Cheung BM,Xu A,Cheung GC,Lam KS

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:To determine the impact of energy restriction (ER) upon the previously reported increased resting and exercise-related oxygen utilization, reduced body temperature, increased serum TSH, and reduced serum free T3 concentrations found during Antarctic residence (AR). DESIGN:Prospective, intervention with both ...

journal_title：Clinical endocrinology

authors： Case HS,Reed HL,Palinkas LA,Reedy KR,Van Do N,Finney NS,Seip R

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:To assess current provision of specialist and transitional paediatric endocrine services in the UK and Ireland. DESIGN:A questionnaire was sent to paediatric endocrinologists requesting details of patients receiving GH and also details of specialist and transitional services. RESULTS:Of 72 questionnaires re...

journal_title：Clinical endocrinology

authors： Kirk J,Clayton P

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:Genetic diagnosis available since 1993 established germinal mutations of the RET proto-oncogene at codon 634 as the main cause of inherited medullary thyroid carcinoma (MTC). International guidelines established in 1999 recommend that children with such mutations undergo a total thyroidectomy before age 5, wi...

journal_title：Clinical endocrinology

authors： Piolat C,Dyon JF,Sturm N,Pinson S,Bost M,Jouk PS,Plantaz D,Chabre O

更新日期：2006-07-01 00:00:00

abstract：:Anti-Müllerian hormone (AMH) is a dimeric glycoprotein, a member of the transforming growth factor (TGF) superfamily. It is produced exclusively in the gonads and is involved in the regulation of follicular growth and development. In the ovary AMH is produced by the granulosa cells of early developing follicles and se...

journal_title：Clinical endocrinology

authors： La Marca A,Volpe A

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:To estimate the frequency of the metabolic syndrome (MS) and of the insulin resistance syndrome (IRS) in overweight or obese French children and to determine the risk factors. DESIGN, PATIENTS AND METHODS:A total of 308 overweight and obese children [166 girls, 142 boys, aged 7-17 years; median body mass ind...

journal_title：Clinical endocrinology

authors： Druet C,Dabbas M,Baltakse V,Payen C,Jouret B,Baud C,Chevenne D,Ricour C,Tauber M,Polak M,Alberti C,Levy-Marchal C

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Peroxisomal proliferator-activated receptors (PPAR)- gamma are expressed abundantly in ACTH-secreting pituitary tumours. The PPAR-gamma activator rosiglitazone has been shown to suppress ACTH secretion in human adrenocorticotroph tumour cells in vitro, and prevent and reduce adrenocorticotroph tumour develop...

journal_title：Clinical endocrinology

authors： Mullan KR,Leslie H,McCance DR,Sheridan B,Atkinson AB

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:Heterozygous inactivating mutations of the calcium-sensing receptor (CaR) gene cause familial hypocalciuric hypercalcaemia (FHH), a generally benign disorder characterized by mild to moderate PTH-dependent hypercalcaemia. We aimed to identify the causative CaR mutations in three families with FHH and examine ...

journal_title：Clinical endocrinology

authors： Ward BK,Magno AL,Blitvich BJ,Rea AJ,Stuckey BG,Walsh JP,Ratajczak T

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the role of pulsed tissue Doppler (TD) to identify left (LV) and right ventricular (RV) myocardial regional involvement in acromegaly. PATIENTS AND MEASUREMENTS:Thirty active acromegaly patients, free of diabetes mellitus, thyroid dysfunction, valvular and coronary heart d...

journal_title：Clinical endocrinology

authors： Galderisi M,Vitale G,Bianco A,Pivonello R,Lombardi G,Divitiis Od,Colao A

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE AND DESIGN:The resistance of macroprolactinomas to dopamine agonist (DA) therapy, whether defined as an absence of PRL normalization or the lack of significant tumour shrinkage after prolonged treatment at high doses, is usually regarded as unpredictable. The aim of this retrospective study, conducted in a te...

journal_title：Clinical endocrinology

authors： Delgrange E,Duprez T,Maiter D

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:To investigate two patients with the hyperparathyroidism-jaw tumour (HPT-JT) syndrome and three patients with familial isolated hyperparathyroidism (FIHP), together with 31 parathyroid tumours (2 HPT-JT, 2 FIHP and 27 sporadic) for HRPT2 mutations. The HPT-JT syndrome and FIHP are autosomal dominant disorders...

journal_title：Clinical endocrinology

authors： Bradley KJ,Cavaco BM,Bowl MR,Harding B,Cranston T,Fratter C,Besser GM,Conceição Pereira M,Davie MW,Dudley N,Leite V,Sadler GP,Seller A,Thakker RV

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:The insulin tolerance test (ITT) has been suggested as the gold standard for diagnosing GH deficiency (GHD). The ITT is, however, potentially hazardous. Glucose monitoring during the ITT varies between centres and there is surprisingly little information on the actual level of blood glucose nadir and the dura...

journal_title：Clinical endocrinology

authors： Holmer H,Link K,Erfurth EM

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:There is little information available about any link between the levels of adiponectin, intercellular adhesion molecule-1 (ICAM-1), tumour necrosis factor-alpha (TNF-alpha) and heart-type fatty acid-binding protein (H-FABP) in coronary atherosclerotic plaque specimens. AIM:To analyse tissue levels of adipon...

journal_title：Clinical endocrinology

authors： Karaduman M,Sengul A,Oktenli C,Pekel A,Yesilova Z,Musabak U,Sanisoglu SY,Gunay C,Baysan O,Kocar IH,Tatar H,Ozata M

更新日期：2006-02-01 00:00:00